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Cell Proliferation

Cell proliferation, the process by which a cell grows and divides to produce two daughter cells, is fundamental to understanding tumorigenesis, where cell cycle disorganization leads to uncontrolled proliferation (Golias et al., 2004).

Proliferation assays are commonly used to evaluate cellular responses to drugs or chemical agents (Adan et al., 2016). These assays often involve the mitotic index or labeling indices using DNA synthesis markers, such as bromodeoxyuridine or tritiated thymidine, or intrinsic markers like Ki67 and proliferative cell nuclear antigen (PCNA) (Goodland, 2017).

The Image-Pro Cell Proliferation protocol is an ideal tool for analyzing these assays, enabling efficient processing of large datasets, including complex formats like multi-well plates. Its intuitive design ensures accessibility for users with little to no image analysis experience.

Techniques: Fluorescence

How it works

Select Channel

Select the channels that contain labelled cells (or nuclei) and the channel that contains the proliferation marker.

Find Cells or Nuclei

Find cells or nuclei with a pre-trained deep learning model, machine learning or threshold segmentation.

Separate from Background

Separate the proliferation marker from the background with either threshold segmentation or machine learning.

Quantitative results

Automatically generate tables, heat maps, charts and even complex bespoke reports.

Measurement parameters supported

Solution requirements

Required Modules

Base

2D Automated Analysis

Cell Biology Protocol Collection

Cell Proliferation Protocol

AI Deep Learning

Life Science Models

Fluorescent Cells Model

RELATED APPS

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Apps are designed for customers with a registered copy of Media Cybernetics software. Please review the App Center specifications tab to ensure your software is supported. To download the App, please fill out the form below.

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